Born Julieta Venegas Percevault on November 24, 1970, in Tijuana, Mexico, Venegas is the daughter of two photographers and is one of five siblings. Her sister, Yvonne Venegas, is a notable photographer whose credits include Ely Guerra and RBD. Julieta embarked on her musical journey at a young age, studying piano from the age of eight. In addition to piano, she also studied musical theory, singing, cello, and violoncello at La Escuela de Música del Noroeste, while she also crossed the U.S. border to study at South Western College in San Diego -- all of this before she even graduated from high school. During her school years she began playing with various bands, including Grupo Chantaje and Tijuana No! (composing one of the latter's more significant hits, "Pobre de Ti").

At age 22 Venegas moved to Mexico City, where she hoped to involve herself with the city's vibrant music scene. Given her talent and beauty, it didn't take her long to make acquaintances, among them Fratta and Café Tacuba. She began writing music for plays around this time, including Calígula Probablemente by Francisco Franco, and she also took up the accordion. Venegas then started a band called La Milagrosa, enlisting Fratta and Rafael González, but when she was offered a contract with BMG, she dropped the idea of forming a band and began work on her solo debut, Aquí (1997), which she recorded in Los Angeles with esteemed producer Gustavo Santaolalla (Café Tacuba, Juanes, Molotov).

In addition to writing the songs on Aquí and singing them, Venegas also played the accordion, piano, and guitar; a number of guests also played on the album, among them brothers Joselo and Enrique Rangel (Café Tacuba), Rafael González (Botellita de Jerez), and Patricio Iglesias (Santa Sabina). BMG released the album in the United States and Spain as well as throughout Latin America, and it won critical acclaim in all corners. Venegas also toured a lot, embarking on the De Viva Voz tour with Ely Guerra and Aurora y la Academia (which stretched across North America) and the Calaveras y Diablitos tour with Los Fabulosos Cadillacs and Aterciopelados (which hit the major cities of Spain). During this same late-'90s era, Venegas contributed her talents to a number of albums by other artists (Enrique Bunbury, Mastretta) and to a number of soundtracks, too (En el País de No Pasa Nada, Amores Perros), and she performed at a number of major festivals as well.

During roughly this same time period, Venegas found time to write and record her second album, Bueninvento (2000). A bit of a departure from her debut, Bueninvento is a full-fledged rock en español album and features a backing band of veteran session men: Joe Gore (guitar), Fernando Saunders (bass), Joey Waronker (drums), and Rick Boston (sax, flutes). More tours and soundtrack contributions followed: the Revolución tour with Jaguares, Jumbo, La Gusana Ciega, and Lisa Flores; the Fémina Rock tour with Aterciopelados, Maria Gabriela Epumer, and others; and the films Demasiado Amor, El Sueño del Caimán, Asesino en Serio, María Llena Eres de Gracia, and Subterra. She also got her first Latin Grammy nominations: Best Rock Song for "Hoy No Queiro" and Best Rock Album for Bueninvento.

Venegas subsequently settled down in Madrid and Buenos Aires to record her third album, Sí (2003), with producers Coti Sorokin and Cachorro López. Six of the album's ten songs were co-written with Sorokin, and the resulting album was a significant change from her past efforts: a colorful pop/rock album. Every song on Sí clocks in between three and four minutes in length; the hooks are memorable and melodic; the music is generally fun and upbeat; and all of it is broadly appealing rather than confrontational, as her past music had often been. Also unlike her past work, Sí took off commercially, going triple platinum in Mexico, topping the album chart there and breaking into the Top Five on the stateside Latin albums chart, and spawning four big hits ("Andar Conmigo," "Lento," "Algo Está Cambiando," "Oleada"), three of them reaching number one in either Mexico or the United States. The success of Sí led to a Latin Grammy for Best Rock Solo Vocal Album in 2004; plus, there were a trio of MTV Music Video Awards, for Best Solo Artist, Best Artist (Mexico), and Artist of the Year.

For her next album, Limón y Sal (2006), Venegas once again worked with producers Coti Sorokin and Cachorro López, and once again came up with a broadly appealing, hit-laden pop/rock album. The lead single, "Me Voy," spent 12 weeks atop the Mexican singles chart; it also was a number one in Spain, a Top Three hit in Italy, and a Top Ten Latin hit in the U.S. A string of follow-up singles (including "Limón y Sal," "Eres Para Mí," and "Primer Día") followed "Me Voy" up the Latin American and European charts (Limón y Sal itself topped charts in Mexico, Columbia, Argentina, Chile, and Central America; plus, it went Top Five in Spain, Top Ten in Switzerland, and Top 200 in the United States). Venegas continued to command heavy airplay for the string of singles from Limón y Sal well into late 2007, at which time a best-of collection, Realmente Lo Mejor, was issued. Meanwhile, the accolades continued: a Grammy in 2007 for Best Latin Pop Album, a Latin Grammy Award in 2006 for Best Alternative Music Album, and a MTV Video Music Award in 2006 for Best Solo Artist. In 2008, Venegas released an MTV Unplugged album.